Efficacy and safety of a second-generation biodegradable polymer sirolimus-eluting stent: One-year results of the CREDIT 2 trial
| Autor: | Shuren Li, Yongping Jia, Bo Xu, Zuyi Yuan, Credit Investigators, Shouli Wang, Yong Sun, Yaling Han, Genshan Ma, Ling Tao, Xiaodong Li, Jinghua Liu, Guosheng Fu, Geng Wang, Huiliang Liu, Kai Xu, Yuejin Yang, Haichang Wang, Kui Pu, Hui Li |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Endpoint Determination medicine.medical_treatment education Coronary Disease 030204 cardiovascular system & hematology Coronary Angiography law.invention 03 medical and health sciences 0302 clinical medicine Percutaneous Coronary Intervention Randomized controlled trial law Absorbable Implants Clinical endpoint Medicine Humans Pharmacology (medical) 030212 general & internal medicine Prospective Studies Aged Pharmacology Sirolimus business.industry Percutaneous coronary intervention Stent Drug-Eluting Stents General Medicine Middle Aged humanities Confidence interval Surgery Clinical trial Treatment Outcome Drug-eluting stent Conventional PCI Female Patient Safety Cardiology and Cardiovascular Medicine business Immunosuppressive Agents |
| Zdroj: | Cardiovascular therapeutics. 36(3) |
| ISSN: | 1755-5922 |
| Popis: | AIMS We performed a multicenter, randomized controlled trial to determine the noninferiority of a novel biodegradable polymer drug-eluting stent (BP-DES), the EXCEL 2 stent, to the first-generation BP-DES, the EXCEL stent. METHODS AND RESULTS Patients (n = 419) scheduled to undergo percutaneous coronary intervention (PCI) were randomized to receive either the EXCEL 2 stent (n = 208) or the EXCEL stent (n = 211) from 15 Chinese centers. At 9 months, primary endpoint in-stent late loss (LL) difference was -0.03 mm (95% confidence interval: -0.09 mm to 0.04 mm) between the EXCEL 2 group (0.14 ± 0.26 mm) and the EXCEL group (0.16 ± 0.36 mm), demonstrating the noninferiority of EXCEL 2 to EXCEL in terms of in-stent LL (P for noninferiority |
| Databáze: | OpenAIRE |
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