Porokeratosis and Cutaneous Malignancy
| Autor: | Abigail D. Krain, Marvin Sasson |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Skin Neoplasms medicine.medical_treatment Hyperkeratosis Dermatology Disseminated superficial actinic porokeratosis Malignancy Risk Factors Epidemiology medicine Humans Risk factor Aged Immunosuppression Therapy business.industry General Medicine Middle Aged medicine.disease Dyskeratosis Porokeratosis Radiation therapy Female Surgery business Precancerous Conditions |
| Zdroj: | Dermatologic Surgery. 22:339-342 |
| ISSN: | 1076-0512 |
| DOI: | 10.1111/j.1524-4725.1996.tb00327.x |
| Popis: | BACKGROUND. Porokeratosis is a disorder of epidermal keratinization manifested clinically by a raised border and histologically by a cornoid lamella. While cutaneous malignancy has been reported to arise in porokeratosis, the risk remains unknown. In the past it has been associated with a history of radiation therapy. OBJECTIVE. The purpose of this study is to estimate the frequency of cutaneous malignancy arising in porokeratosis and define those patients who are at highest risk. METHODS. All cases in the English language literature in the last 30 years were reviewed. RESULTS. Twenty-one (7.5%) of 281 cases reported revealed a malignancy arising within porokeratosis. Large lesions, those of long-standing duration, and the linear type were at greatest risk. Radiation therapy was an infrequently identified risk factor. CONCLUSION. Porokeratosis is a premalignant condition, with certain groups of patients at greatest risk for malignant transformation. |
| Databáze: | OpenAIRE |
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