The Acute Effect of Aminophylline on Left Ventricular Function in Patients with Heart Failure
| Autor: | Hideo Ueda, Hisakazu Yasuda, Iwao Ito, Atsuo Nakanishi, Masamitsu Shiba, Tadashi Koide, Yasuro Sugishita, Hiroshi Tsuyuki, Yasumi Uchida, Kikuo Machida |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Cardiac Catheterization
Cardiac output medicine.medical_specialty Heart Diseases Heart Ventricles medicine.medical_treatment Blood Pressure Stimulation Vasodilation Contractility Heart Rate Internal medicine medicine Humans Mitral Valve Stenosis cardiovascular diseases Cardiac catheterization business.industry Hemodynamics medicine.disease Aminophylline medicine.anatomical_structure Anesthesia Heart failure Hypertension cardiovascular system Cardiology Vascular resistance Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Japanese Heart Journal. 8:121-131 |
| ISSN: | 1348-673X 0021-4868 |
| Popis: | In 10 patients with acquired valvular or hypertensive heart diseases, the acute effects of aminophylline (theophylline ethylenediamine) were studied by the combined left and right cardiac catheterization, calculating the left ventricular volume and circumferential shortening rate using external monitoring of radioisotope dilution. Aminophylline produced a significant increase in cardiac output, left ventricular forward fraction and circumferential shortening rate, and a significant decrease in left ventricular end-diastolic pressure, end-diastolic and end-systolic volume, left ventricular mean force and total peripheral vascular resistance. These results indicate that aminophylline improve the function of failing heart by the stimulation of myocardium and resultant increase in myocardial contractility together with its vasodilating action on peripheral vessels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|