FTO Gene Associates and Interacts with Obesity Risk, Physical Activity, Energy Intake, and Time Spent Sitting: Pilot Study in a Nigerian Population

Autor: Ayonposi Bukola Olaoye, Charles Ayorinde Ologunde, Bolaji Fatai Oyeyemi, Nanfizat Abiket Alamukii
Rok vydání: 2017
Předmět:
Adult
Male
0301 basic medicine
lcsh:Internal medicine
medicine.medical_specialty
Article Subject
Adolescent
Endocrinology
Diabetes and Metabolism
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Black People
Nigeria
Pilot Projects
030209 endocrinology & metabolism
Overweight
Sitting
Polymerase Chain Reaction
FTO gene
Young Adult
03 medical and health sciences
0302 clinical medicine
Risk Factors
Surveys and Questionnaires
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
Obesity
Young adult
lcsh:RC31-1245
Exercise
Life Style
business.industry
Case-control study
nutritional and metabolic diseases
Anthropometry
medicine.disease
030104 developmental biology
Endocrinology
Case-Control Studies
Female
medicine.symptom
Energy Intake
business
Polymorphism
Restriction Fragment Length
Research Article
Zdroj: Journal of Obesity
Journal of Obesity, Vol 2017 (2017)
ISSN: 2090-0716
2090-0708
Popis: Fat mass and obesity-associated (FTO) gene influences obesity but studies have shown that environmental/lifestyle variables like physical activity (PA), time spent sitting (TSS), and energy intake might mediate the effect. However, this is poorly understood in Nigeria due to scarce studies. We demystified association and interaction between FTO rs9939609, obesity, PA, TSS, and energy intake in Nigeria. FTO gene variant was genotyped by restriction fragment length polymorphism and gene sequencing analysis in 103 people with obesity and 98 controls. Anthropometrics and environmental variables were measured using standard procedures. Significant associations were found between FTO rs9939609 with obesity and environmental/lifestyle variables before and after adjusting for age. Carriers of allele A have significantly higher odds of being overweight/obese using BMI [0.191 (0.102–0.361), p<0.001] but this was attenuated by PA (p[interaction]=0.029); odds of being overweight reduced from 0.625 (0.181–2.159) to 0.082 (0.009–0.736) for low and high PA, respectively. Mediation analysis of total indirect effect also confirmed this by showing a simultaneous mediating role of total PA, energy intake, and TSS in the relationship between FTO and BMI (unstandardized-coefficient = 1.68; 95% CI: 1.26–2.22). This study shows a relationship between FTO and obesity phenotype and environmental/lifestyle factors might be an important modulator/mediator in the association.
Databáze: OpenAIRE
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