Evaluation of Ki-67 index in EUS–FNA specimens for the assessment of malignancy risk in pancreatic neuroendocrine tumors
| Autor: | Masahiro Tajika, Yasumasa Niwa, Takuhiro Kohsaki, Susumu Hijioka, T. Tanaka, Yasushi Yatabe, Waki Hosoda, Kenji Yamao, Toshiyuki Hasegawa, Yasuhiro Shimizu, Nobumasa Mizuno, Vikram Bhatia, Shinya Kondo, Hiroshi Imaoka, Isao Nishimori, Taira Kinoshita, Toshiji Saibara, Shinji Iwasaki, Kazuo Hara |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Concordance Kaplan-Meier Estimate Neuroendocrine tumors Malignancy Young Adult Predictive Value of Tests medicine Humans skin and connective tissue diseases Endoscopic Ultrasound-Guided Fine Needle Aspiration Pancreas Grading (tumors) Survival rate Survival analysis Aged Retrospective Studies Aged 80 and over Neoplasm Grading business.industry Gastroenterology Middle Aged medicine.disease digestive system diseases Pancreatic Neoplasms Survival Rate body regions Pancreatic Neuroendocrine Neoplasm Neuroendocrine Tumors Ki-67 Antigen surgical procedures operative ROC Curve Area Under Curve Female Radiology business |
| Zdroj: | Endoscopy. 46:32-38 |
| ISSN: | 1438-8812 0013-726X |
| DOI: | 10.1055/s-0033-1344958 |
| Popis: | BACKGROUND AND STUDY AIM Malignancy in pancreatic neuroendocrine tumors (PNETs) is graded by assessing the resected specimens according to the World Health Organization (WHO) 2010 criteria. The feasibility of such grading using endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) specimens remains unclear. The aim of this study was to ascertain the optimal method of measuring the Ki-67 index in EUS-FNA specimens, using resected specimens as the criterion standard. PATIENTS AND METHODS A total of 58 consecutive patients diagnosed with PNETs between March 1998 and May 2011 were included. The study measured intratumoral Ki-67 index heterogeneity, concordance rates of PNET grading by EUS-FNA with grade of the resected tumor, optimal method of measuring the Ki-67 index in EUS-FNA specimens, and survival analysis based on EUS-FNA specimen grading. RESULTS Intratumoral dispersion of Ki-67 index in resected specimens was 0.033 for Grade 1 and 0.782 for Grade 2 tumors (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|