Hepatic and cardiac and iron overload detected by T2* magnetic resonance (MRI) in patients with myelodisplastic syndrome: A cross-sectional study
| Autor: | L.D.P. Silva, Guilherme Fleury Perini, Fabio P.S. Santos, Nelson Hamerschlak, Ronaldo Hueb Baroni, C. M.B. Nascimento, S. Schuster, L. F. Mantovani, M. S.S. Ribeiro, C. K. Wroclawski, Fernando Uliana Kay, Cesar Higa Nomura, Elvira Deolinda Rodrigues Pereira Velloso, Breno Pannia Espósito |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Iron Overload Adolescent Cross-sectional study Anemia Ferritin levels Chronic myelomonocytic leukemia Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Myelodysplastic–myeloproliferative diseases Internal medicine Prevalence medicine Humans In patient ANEMIA Aged Aged 80 and over medicine.diagnostic_test business.industry Incidence Myocardium Magnetic resonance imaging Hematology Middle Aged medicine.disease Magnetic Resonance Imaging Hepatic Iron Concentration Cell Transformation Neoplastic Cross-Sectional Studies Liver Oncology Myelodysplastic Syndromes 030220 oncology & carcinogenesis Female Symptom Assessment business Brazil 030215 immunology |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2018.12.001 |
| Popis: | Transfusion-dependent anemia and iron overload are associatedwith reduced survival in myelodysplastic syndrome (MDS). This cross-sectional study aimed to evaluate the prevalence of hepatic and cardiac overload in patients with MDS as measured by T2* magnetic resonance imaging (MRI), and its correlation with survival.MDS or chronic myelomonocytic leukemia patients had iron overload evaluated by T2* MRI. HIO was considered when hepatic iron concentration ≥ 2 g/mg. Cardiac iron overload was considered with a T2*-value20 ms.Among 71 patients analyzed, median hepatic iron concentration was 3.9 g/mg (range 0.9-16 g/mg), and 68%of patients had hepatic iron overload. Patients with hepatic iron overload had higher mean ferritin levels (1182 ng/mL versus 185 ng/mL, p 0.0001), transferrin saturation (76% versus 34%, p 0.0001) and lower survival rates. Median cardiac T2*value was 42 ms (range 19.7-70.1 ms), and only one patienthad a T2* value indicative of cardiac iron overload.Hepatic iron overload is found in two thirds of patients, even in cases without laboratory signs of iron overload. Hepatic iron overload by T2* MRI is associated with a decreased risk of survival in patients with MDS. |
| Databáze: | OpenAIRE |
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