A Single Amino Acid Mutation Contributes to Adaptive Beach Mouse Color Pattern
| Autor: | Paul A. Insel, Rachel J. Hirschmann, Hopi E. Hoekstra, Richard A. Bundey, Janet P. Crossland |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Peromyscus Genotype Molecular Sequence Data Adaptation Biological Biology Polymorphism Single Nucleotide Cell Line Gene Frequency Adaptive mutation Cyclic AMP Animals Humans Allele Hair Color Gene Allele frequency Alleles Crosses Genetic Genetics Principal Component Analysis Multidisciplinary Natural selection Pigmentation Sequence Analysis DNA biology.organism_classification Phenotype Amino Acid Substitution Mutation Mutation (genetic algorithm) Crypsis Florida Female Receptor Melanocortin Type 1 geographic locations Hair |
| Zdroj: | Science. 313:101-104 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Natural populations of beach mice exhibit a characteristic color pattern, relative to their mainland conspecifics, driven by natural selection for crypsis. We identified a derived, charge-changing amino acid mutation in the melanocortin-1 receptor ( Mc1r ) in beach mice, which decreases receptor function. In genetic crosses, allelic variation at Mc1r explains 9.8% to 36.4% of the variation in seven pigmentation traits determining color pattern. The derived Mc1r allele is present in Florida's Gulf Coast beach mice but not in Atlantic coast mice with similar light coloration, suggesting that different molecular mechanisms are responsible for convergent phenotypic evolution. Here, we link a single mutation in the coding region of a pigmentation gene to adaptive quantitative variation in the wild. |
| Databáze: | OpenAIRE |
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