RIPK2 NODs to XIAP and IBD
| Autor: | Mads Gyrd-Hansen, Yusuf Topal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Innate immune system biology Pattern recognition receptor X-Linked Inhibitor of Apoptosis Protein Cell Biology Inflammatory Bowel Diseases Ubiquitin ligase Cell biology XIAP 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system Ubiquitin Receptor-Interacting Protein Serine-Threonine Kinase 2 NOD2 Nod1 Signaling Adaptor Protein NOD1 biology.protein Humans 030217 neurology & neurosurgery Developmental Biology |
| Popis: | The receptor-interacting protein kinases (RIPKs) are key regulators of inflammatory signalling and cell death pathways triggered by innate immune receptors, and RIPKs have emerged as promising therapeutic targets for treatment of immune-related disorders. RIPK2 mediates signalling responses initiated by the bacterial-sensing pattern recognition receptors nucleotide-binding oligomerization domain-containing proteins 1 and 2 (NOD1/2), which play a key role in regulation of intestinal immunity and inflammation. Modification of RIPK2 by non-degradative ubiquitin chains generated by the E3 ubiquitin ligase XIAP and other ligases govern NOD1/2 signalling. Recent advances suggest that the interaction between RIPK2 and XIAP is a druggable protein-protein interaction to modulate NOD1/2-dependent immune responses. Here, we discuss the mechanistic function of RIPK2 in immune signalling, its clinical relevance, and the on-going efforts to target RIPK2 in inflammatory bowel disease and beyond. |
| Databáze: | OpenAIRE |
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