Long-Term Outcome of Fetuses with Soft Marker and Without Genetic or Structural Abnormality
| Autor: | Fatma Devran Bildircin, Arif Kokcu, Migraci Tosun, Erdal Malatyalioglu, Gonul Ogur, Handan Celik, Emel Kurtoglu Ozdes, Kubilay Canga, Erhan Yavuz |
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| Přispěvatelé: | OMÜ |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pediatrics
medicine.medical_specialty Aneuploidy Pyelectasis 03 medical and health sciences Epilepsy Fetus 0302 clinical medicine Long-term Medicine 030212 general & internal medicine Ultrasonography Outcome 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Single umbilical artery Follow-up Obstetrics and Gynecology Retrospective cohort study medicine.disease Soft marker Amniocentesis Echogenic Bowel Original Article business Echogenic intracardiac focus |
| Popis: | WOS: 000457467100009 PubMed: 30814811 PurposeTo determine long-term outcome of infants with isolated or multiple soft markers but no structural or chromosomal abnormalities.MethodsA retrospective study of 78 pregnant women who were referred for amniocentesis and found to have soft markers including echogenic intracardiac focus/foci (EIF), echogenic bowel (EB), unilateral or bilateral choroid plexus cysts, (UCPCs or BCPCs) mild pyelectasis and single umbilical artery but no structural anomalies and outcomes of the liveborns with a 4- to 9-year follow-up was conducted.ResultsAmong 28 fetuses with EIF, allergic asthma and epilepsy were diagnosed in two liveborns. We followed up nine pregnancies with EB, epilepsy was present in one case. Allergic asthma was detected in both UCPCs and BCPCs, whereas epilepsy and attention-deficit/hyperactivity disorder (ADHD) were diagnosed in two liveborns with BCPCs. Twelve liveborns with multiple soft markers were evaluated; no pathology was detected in most of them except one case of allergic asthma, one case of hearing impairment and one case of ADHD.ConclusionsThis study shows longer-term favorable outcomes of the liveborns with isolated or multiple soft markers without any aneuploidy and may provide insight into this debated point. |
| Databáze: | OpenAIRE |
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