The tectonigral pathway regulates appetitive locomotion in predatory hunting in mice
| Autor: | Jiayi Zhang, Yuan Xie, Meizhu Huang, Xuerong Zhang, Fangmiao Sun, Yi Wang, Zhiyong Xie, Congping Shang, Dapeng Li, Xiangbing Qi, Xinyu Cheng, Fan Zhang, Huating Gu, Zijun Chen, Miao He, Aixue Liu, Peng Cao, Qing Pei, Yulong Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Superior Colliculi Dopamine Science General Physics and Astronomy Substantia nigra Mice Transgenic Striatum Biology Neural circuits Synaptic Transmission General Biochemistry Genetics and Molecular Biology Article Stereotaxic Techniques 03 medical and health sciences Mice 0302 clinical medicine Reward Motor control Neural Pathways medicine Biological neural network Animals Pars Compacta Motivation Appetitive Behavior Multidisciplinary Pars compacta Superior colliculus Dopaminergic Neurons Dopaminergic General Chemistry 030104 developmental biology nervous system Predatory Behavior Models Animal Excitatory postsynaptic potential Neuroscience 030217 neurology & neurosurgery Locomotion medicine.drug |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Appetitive locomotion is essential for animals to approach rewards, such as food and prey. The neuronal circuitry controlling appetitive locomotion is unclear. In a goal-directed behavior—predatory hunting, we show an excitatory brain circuit from the superior colliculus (SC) to the substantia nigra pars compacta (SNc) to enhance appetitive locomotion in mice. This tectonigral pathway transmits locomotion-speed signals to dopamine neurons and triggers dopamine release in the dorsal striatum. Synaptic inactivation of this pathway impairs appetitive locomotion but not defensive locomotion. Conversely, activation of this pathway increases the speed and frequency of approach during predatory hunting, an effect that depends on the activities of SNc dopamine neurons. Together, these data reveal that the SC regulates locomotion-speed signals to SNc dopamine neurons to enhance appetitive locomotion in mice. Goal-oriented movement is a fundamental animal behaviour. Here, the authors show that neurons in the superior colliculus project to the substantia nigra pars compacta, regulating dopaminergic signaling and specifically appetitive locomotion in mice. |
| Databáze: | OpenAIRE |
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