New method for reducing viscosity and shear stress in hydrogel 3D printing via multidimension vibration

Autor:	Sheng Lin, Bicong Li, Liang Yang, Yun Zhai, Xiaoyu Wang, Chun Wang
Rok vydání:	2022
Předmět:	Human-Computer Interaction Tissue Engineering Tissue Scaffolds Viscosity Printing Three-Dimensional Bioprinting Biomedical Engineering Hydrogels Bioengineering General Medicine Vibration Computer Science Applications
Zdroj:	Computer Methods in Biomechanics and Biomedical Engineering. 25:1796-1811
ISSN:	1476-8259 1025-5842
DOI:	10.1080/10255842.2022.2039129
Popis:	Microextrusion 3D bioprinting is a comparatively easy method to fabricate structures in tissue engineering. But high viscosity and wall shear stress in the tube and nozzle often lead to low cell survival rate of printed tissue. To reduce the viscosity and shear stress of materials in biological 3D printing, a multidimension microvibration assisted hydrogel 3D printing method was proposed. The compliant mechanism driven by piezoceramic was applied to 3D printing of hydrogels. The shear stress and viscosity of hydrogels could be effectively reduced by multidimension microvibration. Simulation analysis of the extrusion device was carried out to study the influence of vibration parameters on viscosity and shear stress, and optimized multidimension vibration forms and vibration parameters were selected for experiments. The experiment results show that multidimension microvibration can effectively reduce the viscosity of hydrogels and improve printing resolution and print speed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdeb3c6e6cec5d28251005cea58312e6 https://doi.org/10.1080/10255842.2022.2039129 Zobrazit plný text záznamu