Congenital cardiovascular malformations in twins and triplets from a population-based study
| Autor: | Charlotte Ferencz, Jacqueline A. Astemborski, Kate A. Berg, Joann A. Boughman |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Heart Defects
Congenital Male Pediatrics medicine.medical_specialty Triplets Singleton business.industry Dizygotic twin Concordance Infant Newborn Monozygotic twin Population based study Sex Factors Pediatrics Perinatology and Child Health medicine Diseases in Twins Humans Cardiovascular malformations Female business |
| Zdroj: | American journal of diseases of children (1960). 143(12) |
| ISSN: | 0002-922X |
| Popis: | • Data from the Baltimore-Washington Infant Study of congenital cardiovascular malformations permitted detailed analysis of congenital cardiovascular malformations in 62 twins and 3 triplets and 2303 singleton cases. A probability sample of controls (n = 2793) included 43 twins. The case prevalence of multiple births was 28 of 1000, compared with a 15 of 1000 prevalence among controls χ2= 5.7). There were more girls among case twins than among case singletons and controls χ2= 9.0). Monozygosity was no more frequent in case twins than in controls. Looping defects occurred in 4 monozygotic twin pairs compared with only 1 dizygotic twin pair. The twinning process itself may be implicated in the development of congenital cardiovascular malformations in some of these infants, especially those with looping defects, but concordance of types of defects in 4 of 65 pairs implicates genetic factors in the determination of some forms of congenital cardiovascular malformations. (AJDC.1989;143:1461-1463) |
| Databáze: | OpenAIRE |
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