Dimethyl sulfoxide enhances effectiveness of skin antiseptics and reduces contamination rates of blood cultures
| Autor: | Kenneth V. I. Rolston, Jeffrey J. Tarrand, Dimitrios P. Kontoyiannis, Xiang Yang Han, Paul R. LaSala |
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| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.drug_class Alcohol Microbiology 2-Propanol chemistry.chemical_compound Antiseptic Staphylococcus epidermidis medicine Humans Blood culture Dimethyl Sulfoxide Skin Microbial Viability medicine.diagnostic_test biology Dimethyl sulfoxide business.industry Nosocomial transmission Drug Synergism Bacteriology Contamination Middle Aged biology.organism_classification Bacterial Load Solvent Blood chemistry Anti-Infective Agents Local Female business Iodine |
| Zdroj: | Journal of clinical microbiology. 50(5) |
| ISSN: | 1098-660X |
| Popis: | Effective skin antisepsis is of central importance in the prevention of wound infections, colonization of medical devices, and nosocomial transmission of microorganisms. Current antiseptics have a suboptimal efficacy resulting in substantial infectious morbidity, mortality, and increased health care costs. Here, we introduce an in vitro method for antiseptic testing and a novel alcohol-based antiseptic containing 4 to 5% of the polar aprotic solvent dimethyl sulfoxide (DMSO). The DMSO-containing antiseptic resulted in a 1- to 2-log enhanced killing of Staphylococcus epidermidis and other microbes in vitro compared to the same antiseptic without DMSO. In a prospective clinical validation, blood culture contamination rates were reduced from 3.04% for 70% isopropanol–1% iodine (control antiseptic) to 1.04% for 70% isopropanol–1% iodine–5% DMSO ( P < 0.01). Our results predict that improved skin antisepsis is possible using new formulations of antiseptics containing strongly polarized but nonionizing (polar aprotic) solvents. |
| Databáze: | OpenAIRE |
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