Association of inflammatory factors and aging in Parkinson's disease
| Autor: | Cheng-Jie Mao, Han-Ying Gu, Hong Jin, Jing Chen, Chun-Feng Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Oncology Aging medicine.medical_specialty Parkinson's disease Lymphocyte Protective factor Inflammation Disease Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Risk factor Aged business.industry General Neuroscience Parkinson Disease Middle Aged medicine.disease C-Reactive Protein 030104 developmental biology medicine.anatomical_structure Female medicine.symptom business Biomarkers 030217 neurology & neurosurgery Lipoprotein |
| Zdroj: | Neuroscience Letters. 736:135259 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2020.135259 |
| Popis: | Parkinson's disease as a common neurodegenerative disease, has been found to be related to inflammation. So we observed the characteristics of inflammatory indexes in patients with Parkinson's disease and investigated the relationship between inflammatory cytokines and clinical characteristics. Emerging data may reveal novel neuroinflammatory pathways and identify new targets for treatment of Parkinson's disease.We examined the inflammatory indexes in 183 patients and 89 healthy controls in association with clinical characteristics.Patients had significantly higher levels of monocytes, neutrophils, high-sensitivity C-reactive protein, and monocyte-to-high-density lipoprotein ratios (p 0.01) and lower levels of lymphocytes (p = 0.02) than the controls. There were no significant differences in age, leukocytes, high-density lipoprotein, or neutrophil-lymphocyte ratios between the two groups (p 0.05). Multivariate logistic regression analysis of these indicators revealed that lymphocyte level was a protective factor (p = 0.025, OR=-0.679), while high-sensitivity C-reactive protein level was a risk factor (p = 0.000, OR=1.168) for Parkinson's disease. High-sensitivity C-reactive protein levels were higher in older Parkinson's disease patients.High-sensitivity C-reactive protein is positively related to the risk of Parkinson's disease, especially in aging patients. High-sensitivity C-reactive protein is a potential biomarker for disease progression and treatment response for Parkinson's disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect