PHARMACOKINETICS OF ALCURONIUM IN ELDERLY PATIENTS UNDERGOING TOTAL HIP REPLACEMENT OR AORTIC RECONSTRUCTIVE SURGERY
| Autor: | P. C. Ho, E. J. Triggs, David W.A. Bourne, I.D. Stephens, A.M. Holloway |
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| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Reconstructive surgery Time Factors medicine.medical_treatment Hemorrhage Toxiferine Aortic aneurysm Postoperative Complications Pharmacokinetics medicine.artery medicine Humans Alcuronium Intraoperative Complications Aged Volume of distribution Aorta business.industry Middle Aged medicine.disease Aortic Aneurysm Surgery Kinetics Anesthesiology and Pain Medicine Anesthesia Orthopedic surgery Fluid Therapy Female Hip Prosthesis business Fluid replacement |
| Zdroj: | British Journal of Anaesthesia. 56:465-471 |
| ISSN: | 0007-0912 |
| DOI: | 10.1093/bja/56.5.465 |
| Popis: | The pharmacokinetic behaviour of alcuronium was studied in three patients undergoing resection of an aortic aneurysm, and in another two patients undergoing total hip replacement (group I). A control group of five elderly patients undergoing relatively minor surgery was included (group II). In group I patients, the values of the pharmacokinetic parameters such as plasma clearance, elimination half-life and the apparent volume of distribution of the drug were found to be comparable to those obtained in normal young patients in previous studies. The group II patients, however, were found to have a prolonged elimination half-life as a result of reduced plasma clearance, possibly an age-related effect. The differences between these two groups of patients may be explained by the differences in the extent of haemorrhage and fluid replacement or changes in blood circulation, or both. However, alcuronium must still be used cautiously in both groups of patients, especially in the light of a recent finding that patients undergoing aortic reconstructive surgery have a high frequency of functional renal failure after operation. |
| Databáze: | OpenAIRE |
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