A human embryonic stem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis
| Autor: | Xiaoxing Liang, Shaojun Liang, Zhanwen Cheng, Francesco Faiola, Nuoya Yin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Environmental Engineering
Human Embryonic Stem Cells Developmental toxicity Inflammation 010501 environmental sciences 01 natural sciences 03 medical and health sciences SOX2 Ultrafine particle medicine Humans Psoriasis Environmental Chemistry 0105 earth and related environmental sciences General Environmental Science Air Pollutants 0303 health sciences Chemistry 030311 toxicology General Medicine Embryonic stem cell Cell biology CXCL1 CXCL2 CXCL3 Particulate Matter medicine.symptom |
| Zdroj: | Journal of Environmental Sciences. 87:194-204 |
| ISSN: | 1001-0742 |
| Popis: | Air pollution has been linked to many health issues, including skin conditions, especially in children. Among all the atmospheric pollutants, ultrafine particles have been deemed very dangerous since they can readily penetrate the lungs and skin, and be absorbed into the bloodstream. Here, we employed a human embryonic stem cell (hESC)-based differentiation system towards keratinocytes, to test the effects of ultrafine carbon particles, which mimic ambient ultrafine particles, at environment related concentrations. We found that 10 ng/mL to 10 μg/mL ultrafine carbon particles down-regulated the expression of the pluripotency marker SOX2 in hESCs. Moreover, 1 μg/mL to 10 μg/mL carbon particle treatments disrupted the keratinocyte differentiation, and up-regulated inflammation- and psoriasis-related genes, such as IL-1β, IL-6, CXCL1, CXCL2, CXCL3, CCL20, CXCL8, and S100A7 and S100A9, respectively. Overall, our results provide a new insight into the potential developmental toxicity of atmospheric ultrafine particles. |
| Databáze: | OpenAIRE |
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