Dynamic mesolimbic dopamine signaling during action sequence learning and expectation violation
| Autor: | Kay E. Linker, Kate M. Wassum, Venuz Y. Greenfield, Jeffrey K. Bye, Anne L. Collins, Alice S. Wang |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male Dopamine Nucleus accumbens Bioinformatics Spatial memory Nucleus Accumbens Article Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Discrimination Psychological Reward Task Performance and Analysis medicine Animals Learning Sequence (medicine) Multidisciplinary Overtraining medicine.disease 030104 developmental biology Action (philosophy) Sequence learning Signal transduction Stereotyped Behavior Psychology Neuroscience 030217 neurology & neurosurgery medicine.drug Signal Transduction |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Prolonged mesolimbic dopamine concentration changes have been detected during spatial navigation, but little is known about the conditions that engender this signaling profile or how it develops with learning. To address this, we monitored dopamine concentration changes in the nucleus accumbens core of rats throughout acquisition and performance of an instrumental action sequence task. Prolonged dopamine concentration changes were detected that ramped up as rats executed each action sequence and declined after earned reward collection. With learning, dopamine concentration began to rise increasingly earlier in the execution of the sequence and ultimately backpropagated away from stereotyped sequence actions, becoming only transiently elevated by the most distal and unexpected reward predictor. Action sequence-related dopamine signaling was reactivated in well-trained rats if they became disengaged in the task and in response to an unexpected change in the value, but not identity of the earned reward. Throughout training and test, dopamine signaling correlated with sequence performance. These results suggest that action sequences can engender a prolonged mode of dopamine signaling in the nucleus accumbens core and that such signaling relates to elements of the motivation underlying sequence execution and is dynamic with learning, overtraining and violations in reward expectation. |
| Databáze: | OpenAIRE |
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