Myelin lipids of the rat brain in experimental hypoxia
| Autor: | Stanisławska J, Z. Adamczewska-Goncerzewicz, Pankrac J, D. Talkowska, Wender M, A. Grochowalska |
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| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
chemistry.chemical_element Biology Oxygen Pathology and Forensic Medicine Lesion Myelin chemistry.chemical_compound Internal medicine medicine Animals Respiratory system Hypoxia Brain Myelin Sheath Phospholipids Brain Chemistry Cholesterol Lysophosphatidylcholines Rats Inbred Strains Hypoxia (medical) Lipid Metabolism Rats Endocrinology Membrane medicine.anatomical_structure Lysophosphatidylcholine Biochemistry chemistry Cholesterol Esters medicine.symptom |
| Zdroj: | Experimental pathology. 33:59-63 |
| ISSN: | 0232-1513 |
| Popis: | Summary The pattern of cerebral myelin lipids was studied in Wistar rats exposed to mild hypoxia (7% of oxygen in a respiratory mixture) for 30 min. The most pronounced change involved a marked increase in cholesterol esters and lysophosphatidylcholine content in the myelin fraction. The results obtained indicate that mild hypoxia induces a lesion of myelin membranes but does not provoke the reaction of lymphocytes and macrophages, which by production of myelinolytic factors, evoke demyelination. |
| Databáze: | OpenAIRE |
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