The Cannabinoids Effect on Bone Formation and Bone Healing
| Autor: | Bitya Raphael-Mizrahi, Yankel Gabet |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cannabinoid receptor Endocrinology Diabetes and Metabolism medicine.medical_treatment Osteoporosis 030209 endocrinology & metabolism Bone healing Pharmacology Receptor Cannabinoid CB2 03 medical and health sciences Mice 0302 clinical medicine Sex Factors Receptor Cannabinoid CB1 Osteogenesis medicine Cannabinoid receptor type 2 Animals Cannabidiol Humans Bone regeneration Fracture Healing business.industry Cannabinoids medicine.disease Endocannabinoid system Rats 030104 developmental biology lipids (amino acids peptides and proteins) Cannabinoid business medicine.drug Endocannabinoids |
| Zdroj: | Current osteoporosis reports. 18(5) |
| ISSN: | 1544-2241 |
| Popis: | Here, we overview the latest findings from studies investigating the skeletal endocannabinoid (EC) system and its involvement in bone formation and resorption. The endocannabinoid system consists of endogenous ligands, receptors, and enzymes. The main cannabinoids found in the cannabis plant are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Cannabinoid receptors CB1 and CB2 are expressed in bone and regulate bone homeostasis in rodents and humans. CBD treatment was shown to enhance fracture healing in rats. Recent studies in mice indicate that strain, age, and sex differences dictate the skeletal outcome of the EC activation. CBD treatment was shown to enhance bone healing, but needs validation in clinical trials. While research shows that EC activity protects against bone loss, studies on CB1 and CB2 agonists in bone regeneration models are lacking. Whether modulating the EC system would affect bone repair remains therefore an open question worth investigating. |
| Databáze: | OpenAIRE |
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