Adipose tissue transplantation ameliorates lipodystrophy-associated metabolic disorders in seipin-deficient mice
| Autor: | Xiao-Yue Wu, Fang Xu, Pengfei Xu, Xuejing Liu, Zihao Zhou, Abudurexiti Kayoumu, Jingyi Li, George Liu, Bei-Chen Xie, Xiaomin Huang, Wei Huang, Huan Wang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Leptin medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism Subcutaneous Fat Adipose tissue 030209 endocrinology & metabolism Fatty Acids Nonesterified Seipin Congenital generalized lipodystrophy 03 medical and health sciences Mice 0302 clinical medicine Insulin resistance Lipodystrophy Congenital Generalized Physiology (medical) Internal medicine GTP-Binding Protein gamma Subunits medicine Animals Triglycerides Dyslipidemias Mice Knockout business.industry Glucose Tolerance Test medicine.disease Lipid Metabolism Heterotrimeric GTP-Binding Proteins Transplantation Fatty Liver 030104 developmental biology Endocrinology Liver Lipodystrophy business Dyslipidemia |
| Zdroj: | American journal of physiology. Endocrinology and metabolism. 316(1) |
| ISSN: | 1522-1555 |
| Popis: | Seipin deficiency is responsible for type 2 congenital generalized lipodystrophy with severe loss of adipose tissue and can lead to hepatic steatosis, insulin resistance (IR), and dyslipidemia in humans. Adipose tissue secretes many adipokines that are central to the regulation of metabolism. In this study, we investigated whether transplantation of normal adipose tissue could ameliorate severe hepatic steatosis, IR, and dyslipidemia in lipoatrophic seipin knockout (SKO) mice. Normal adipose tissue from wild-type mice was transplanted into 6-wk-old SKO mice. At 4 mo after adipose tissue transplantation (AT), the transplanted fat survived with detectable blood vessels, and the reduced levels of plasma leptin, a major adipokine, were dramatically increased. Severe hepatic steatosis, IR, and dyslipidemia in SKO mice were ameliorated after AT. In addition, abnormal hepatic lipogenesis and β-oxidation gene expression in SKO mice were improved after AT. Our results suggest that AT may be an effective treatment to improve lipodystrophy-associated metabolic disorders. |
| Databáze: | OpenAIRE |
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