Comparative analysis of physical doses and biomarker changes in subjects underwent Computed Tomography, Positron Emission Tomography-Computed Tomography, and interventional procedures
| Autor: | Santhosh Joseph, Tamizh Selvan Gnana Sekaran, Venkateswarlu Raavi, Safa Abdul Syed Basheerudeen, Panneerselvam Shanmugam, Sudha Pattan, Karthik Kanagaraj, Annalakshmi Ozimuthu, Akshaya Prasad, Venkatachalam Perumal, Shangamithra Visweswaran |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Health Toxicology and Mutagenesis Population Computed tomography Ionizing radiation Young Adult Positron Emission Tomography Computed Tomography Genetics Medicine Dosimetry Humans Positron emission education Aged Aged 80 and over education.field_of_study medicine.diagnostic_test business.industry Dose-Response Relationship Radiation Middle Aged Dose area product Absorbed dose Case-Control Studies Biomarker (medicine) Female business Nuclear medicine Biomarkers |
| Zdroj: | Mutation research. Genetic toxicology and environmental mutagenesis. |
| ISSN: | 1879-3592 |
| Popis: | Even though the medical uses of ionizing radiation are well-acknowledged globally as vital tools for the improvement of human health, they also symbolize the major man-made sources of radiation exposure to the population. Estimation of absorbed dose and biological changes after radiation-based imaging might help to better understand the effects of low dose radiation. Because of this, we measured the Entrance Surface Dose (ESD) at different anatomical locations using Lithium tetraborate doped with manganese (Li2B4O7: Mn), recorded Dose Length Product (DLP) and Dose Area Product (DAP), analyzed Chromosomal Aberration (CA), Micronucleus (MN), gamma-H2AX (γ-H2AX), and p53ser15 proteins in the blood lymphocytes of patients (n = 267) underwent Computed Tomography (CT), Positron Emission Tomography-CT (PET/CT), and interventional procedures and healthy volunteers (n = 19). The DLP and effective doses obtained from PET/CT procedures were significantly higher (p 0.05) between pre- and post-procedure. However, the relative fluorescence intensity of γ-H2AX and p53ser15 was >1 in 58.5 % and 65.8 % of subjects respectively. Large inter-individual variation and lack of correlation between physical dose and biomarkers suggest the need for robust dosimetry with a large sample size to understand the health effects of low dose radiation. |
| Databáze: | OpenAIRE |
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