Possible involvement of lactate in neuroglial interaction through nicotinic cholinergic synapses in the cranial cervical sympathetic ganglion
| Autor: | P. L. Gorelikov, S. V. Savelyev |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Nicotinic Antagonists
Superior Cervical Ganglion Receptors Nicotinic Biology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Lactate dehydrogenase medicine Animals Lactic Acid Cholinergic synapse L-Lactate Dehydrogenase General Medicine Cervical sympathetic ganglion Blockade Ganglion Isoenzymes Nicotinic agonist medicine.anatomical_structure chemistry Pipecolic Acids Synapses Cholinergic Rabbits Ldh activity Lactate Dehydrogenase 5 Neuroglia Neuroscience |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 142:625-627 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-006-0434-3 |
| Popis: | Activities of LDH and its H- and M-isoforms in neurons and satellite gliocytes of the cranial cervical sympathetic ganglion in rabbits under normal conditions and during nicotinic cholinergic synapse blockade were evaluated by integral cytophotometry in tissue sections. Normally activity of H-isoform predominates in neurons and M-isoform in satellite gliocytes. Blockade of the cranial cervical sympathetic ganglion significantly decreased LDH activity (H- and M-isoforms) in neurons in direct proportion to the number of blocked nicotinic cholinergic receptors. Activity of M-isoform in satellite gliocytes decreased with increasing the degree of blockade, while activity of H-isoform did not change. The isoenzyme profile of LDH in satellite gliocytes reached the level of intact neurons. Presumably, lactate production in satellite gliocytes is regulated by sympathetic neurons through nicotinic cholinergic synapses. |
| Databáze: | OpenAIRE |
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