Radioresistant tumor cell lines derived from head and neck radiation failures
| Autor: | Ralph R. Weichselbaum, Michael A. Beckett, Anatoly Dritschilo, Everett E. Vokes, William J. Moran, Michael E. Goldman, Allen G. Tybor, William R. Panje, Srinivasan Vijayakumar, Susan Ahmed-Swan, Jeffrey L. Schwartz |
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| Rok vydání: | 1989 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry medicine.medical_treatment Head and neck cancer medicine.disease Radiation Tolerance In vitro Ionizing radiation Radiation therapy Otorhinolaryngology Head and Neck Neoplasms Cell culture Radioresistance Carcinoma Squamous Cell Tumor Cells Cultured medicine Humans Cytotoxic T cell Sarcoma business |
| Zdroj: | Head & Neck. 11:343-348 |
| ISSN: | 1097-0347 1043-3074 |
| DOI: | 10.1002/hed.2880110410 |
| Popis: | We studied the in vitro radiobiological parameters of 16 human head and neck squamous cell carcinoma tumor cell lines cultured from patients who suffered local failure after a curative course of radiotherapy. The radiobiological parameters determined included D0, n, and D. When compared with in vitro radiobiological parameters of tumor cells cultured from head and neck cancer patients prior to radiotherapy, human sarcoma cell lines, and normal human diploid fibroblasts studied in our laboratory (as well as other human tumor cell lines reported in the literature), tumor cells derived from radiotherapy failures on average are resistant to the cytotoxic effects of ionizing radiation. |
| Databáze: | OpenAIRE |
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