Regulation of cell number in the mammary gland by controlling the exfoliation process in milk in ruminants
| Autor: | Hélène Quesnel, Lucile Herve, Marion Boutinaud, Vanessa Lollivier |
|---|---|
| Přispěvatelé: | Physiologie, Environnement et Génétique pour l'Animal et les Systèmes d'Elevage [Rennes] (PEGASE), AGROCAMPUS OUEST-Institut National de la Recherche Agronomique (INRA), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
[SDV]Life Sciences [q-bio] Mammary gland Apoptosis Lactation dairy cows cellular proliferation Goats food and beverages Ruminants Exfoliation joint Milk medicine.anatomical_structure Mammary Epithelium vache laitière Female Steroids mammary epithelial cell Serotonin medicine.medical_specialty Biology Milking milk yield 03 medical and health sciences Mammary Glands Animal Internal medicine Genetics medicine Animals cellule épithéliale mammaire production de lait Cell Proliferation prolifération cellulaire apoptose chèvre laitière Cell growth dairy cow Epithelial Cells biochemical phenomena metabolism and nutrition medicine.disease exfoliation Prolactin Diet Mastitis body regions 030104 developmental biology Endocrinology dairy goat Cattle Animal Science and Zoology Food Science |
| Zdroj: | Journal of Dairy Science Journal of Dairy Science, American Dairy Science Association, 2016, 99 (1), pp.854-863. ⟨10.3168/jds.2015-9964⟩ |
| ISSN: | 0022-0302 |
| Popis: | Presented as part of the Lactation Biology: Mammary Gland Biology Revisited Symposium at the ADSA-ASAS Joint Annual Meeting, Orlando, Florida, July 2015.; Milk yield is partly influenced by the number of mammary epithelial cells (MEC) in the mammary gland. It is well known that variations in MEC number are due to cell proliferation and apoptosis. The exfoliation of MEC from the mammary epithelium into milk is another process that might influence MEC number in the mammary tissue. The rate of MEC exfoliation can be assessed by measuring the milk MEC content through light microscopy, flow cytometry analysis, or an immuno-magnetic method for MEC purification. Various experimental models have been used to affect milk yield and study the rate of MEC exfoliation. Reducing milking frequency from twice to once daily did not seem to have any effect on MEC loss in goat and cow milk after 7 d, but increased MEC loss per day in goats when applied for a longer period. An increase in MEC exfoliation was also observed during short days as compared with long days, or in response to an endotoxin-induced mastitis in cows. Other animal models were designed to investigate the endocrine control of the exfoliation process and its link with milk production. Suppression of ovarian steroids by ovariectomy resulted in a greater persistency of lactation and a decrease in MEC exfoliation. Administering prolactin inhibitors during lactation or at dry-off enhanced MEC exfoliation, whereas exogenous prolactin during lactation tended to prevent the negative effect of prolactin inhibitors. These findings suggest that prolactin could regulate MEC exfoliation. In most of these studies, variations of MEC exfoliation were associated with variations in milk yield and changes in mammary epithelium integrity. Exfoliation of MEC could thus influence milk yield by regulating MEC number in mammary tissue. |
| Databáze: | OpenAIRE |
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