Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects
| Autor: | Daniela Sales Alviano Moreno, Patricia Dias Fernandes, Darlisson de Alexandria Santos, Péricles Barreto Alves, Celuta S. Alviano, Dayana da Costa Salomé, Natália de Morais Cordeiro, Tayna S. Valerio |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Leukocyte migration
medicine.drug_class Aristolochia trilobata Medicine (miscellaneous) (+)-Naloxone Sulcatyl acetate Pharmacology 030226 pharmacology & pharmacy Article General Biochemistry Genetics and Molecular Biology Anti-inflammatory 03 medical and health sciences 0302 clinical medicine medicine anti-inflammatory activity lcsh:QH301-705.5 biology Chemistry Nitric oxide synthase Nociception lcsh:Biology (General) Opioid Enzyme inhibitor biology.protein Licking antinociceptive effect 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Biomedicines, Vol 8, Iss 111, p 111 (2020) Biomedicines Volume 8 Issue 5 |
| ISSN: | 2227-9059 |
| DOI: | 10.3390/biomedicines8050111 |
| Popis: | Aristolochia trilobata, popularly known as &ldquo mil-homens,&rdquo is widely used for treatment of stomach aches, colic, asthma, pulmonary diseases, diabetes, and skin affection. We evaluated the antinociceptive and anti-inflammatory activities of the essential oil (EO) and the main constituent, 6-methyl-5-hepten-2-yl acetate (sulcatyl acetate, SA). EO and SA (1, 10, and 100 mg/kg, p.o.) were evaluated using chemical (formalin-induced licking) and thermal (hot-plate) models of nociception or inflammation (carrageenan-induced cell migration into the subcutaneous air pouch, SAP). The mechanism of antinociceptive activity was evaluated using opioid, cholinergic receptor antagonists (naloxone and atropine), or nitric oxide synthase inhibitor (L-NAME). EO and SA presented a central antinociceptive effect (the hot-plate model). In formalin-induced licking response, higher doses of EO and SA also reduced 1st and 2nd phases. None of the antagonists and enzyme inhibitor reversed antinociceptive effects. EO and SA reduced the leukocyte migration into the SAP, and the cytokines tumor necrosis factor and interleukin-1 (TNF-&alpha and IL-1&beta respectively) produced in the exudate. Our results are indicative that EO and SA present peripheral and central antinociceptive and anti-inflammatory effects. |
| Databáze: | OpenAIRE |
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