Association of resistin and adiponectin with different clinical blood pressure phenotypes
| Autor: | Thomas Makris, A Bratsas, O. Papazachou, Dimitrios Papadopoulos, N Rodolakis, Despoina Perrea, M V Papavasileiou, Costas Thomopoulos, M Daskalaki |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Ambulatory blood pressure Office Visits Adipokine Blood Pressure White coat hypertension Risk Factors Internal medicine Diabetes mellitus Internal Medicine medicine Humans Resistin Adiponectin business.industry Middle Aged medicine.disease Masked Hypertension Cross-Sectional Studies Logistic Models Phenotype Blood pressure Endocrinology Cardiovascular Diseases Hypertension Female business |
| Zdroj: | Journal of Human Hypertension. 25:38-46 |
| ISSN: | 1476-5527 0950-9240 |
| DOI: | 10.1038/jhh.2010.22 |
| Popis: | We investigated whether the resistin (Res) and adiponectin (Adp) levels are associated with different clinical blood pressure (BP) phenotypes. Among 465 consecutive never-treated white subjects, we excluded those with diabetes mellitus; impaired glucose metabolism; history of any cardiovascular disease or other concurrent medical condition; secondary hypertension; ongoing vasoactive treatment. Three separate clinic BP measurements and ambulatory BP monitoring were implemented to divide 328 subjects (aged 48±6 years; 172 males) into hypertensives (n=105), masked hypertensives (n=41), white-coat hypertensives (n=52) and normotensives (n=130). Participants underwent echocardiography and oral glucose tolerance testing, whereas, from fasting venous blood samples metabolic profile, plasma Res and Adp levels were assessed. Hypertensives and masked hypertensives showed higher log(10)(Res) and lower log(10)(Adp) levels compared with normotensives, whereas white-coat hypertensives had similar levels of these adipokines compared with normotensives. Common correlates for both of the adipokines were 24-h systolic BP, standing/sitting difference of both diastolic BP and heart rate, and waist circumference. Hypertensive and masked hypertensive compared with normotensive phenotype were independently associated with log(10)(Res) with odds ratios of 1.24 (1.08-1.44), and 1.16 (1.09-1.34) and log(10)(Adp) with 0.74 (0.65-0.87), and 0.81 (0.67-0.95), respectively. Increased Res and decreased Adp plasma levels are associated with out-of-clinic hypertension, whereas they did not determine white-coat hypertension. |
| Databáze: | OpenAIRE |
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