NF-κΒ and SOD expression in preeclamptic placentas
| Autor: | Abraham Silva Carmona, Hugo Mendieta Zerón |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Placenta Preeclampsia Superoxide dismutase 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Pregnancy Internal medicine medicine Humans RNA Messenger reproductive and urinary physiology Analysis method Messenger RNA 030219 obstetrics & reproductive medicine biology business.industry Superoxide Dismutase NF-kappa B General Medicine medicine.disease female genital diseases and pregnancy complications 030104 developmental biology Endocrinology Real-time polymerase chain reaction embryonic structures Familial history biology.protein Maternal death Female business |
| Zdroj: | Turkish journal of medical sciences. 46(3) |
| ISSN: | 1300-0144 |
| Popis: | Background/aim Preeclampsia is a leading cause of maternal death in the developing world. Our aim was to quantify and compare messenger (mRNA) expression of nuclear factor-kappa beta (NF-κΒ) and superoxide dismutase (SOD) in control patients with preeclampsia and without preeclampsia with or without familial hereditary background. Materials and methods Four groups of patients were formed depending on the presence or absence of preeclampsia and presence or absence of familial history for preeclampsia. NF-κΒ and SOD were measured in human placentas by real-time quantitative polymerase chain reaction. The 2-ΔΔct analysis method was used to measure the difference in the relative expression of the target genes in each group of patients. Results In NF-κΒ expression, there was an increase of 23.35% in the group of women with preeclampsia versus women with preeclampsia without familial history. Regarding SOD, there was a reduction of about 33.33% in the expression in women with preeclampsia with familial history versus women with preeclampsia without familial history. Conclusion Familial presence of preeclampsia could predispose to altered expression in SOD and NF-κΒ. |
| Databáze: | OpenAIRE |
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