Cytotoxic triterpenes from Salvia buchananii roots
| Autor: | Khadidja Aya Beladjila, Roberta Cotugno, Zahia Kabouche, Marinella De Leo, Alessandra Braca, Djemaa Berrehal, Nunziatina De Tommasi |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Salvia buchananii
pentacyclic triterpenes Stereochemistry Plant Science Biology Plant Roots 01 natural sciences Biochemistry Analytical Chemistry HeLa Terpene Jurkat Cells Triterpene Humans Cytotoxic T cell Salvia cytotoxic activity chemistry.chemical_classification phenolic derivatives salvibuchanic acid Cytostatic Agents Cytotoxins HeLa Cells MCF-7 Cells Molecular Structure Spectrum Analysis Triterpenes 010405 organic chemistry Organic Chemistry biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Cell culture Lamiaceae Pentacyclic Triterpenes |
| Popis: | A pentacyclic triterpene, named salvibuchanic acid (1), together with five known compounds, were isolated from the roots of Salvia buchananii Hedge (Lamiaceae). The structural characterisation of all compounds was performed by spectroscopic analyses, including 1D and 2D NMR and HRESIMS experiments. The lupane triterpene (1) and hyptadienic acid (2) were investigated for their potential cytotoxic activity on Jurkat, HeLa and MCF7 cell lines. Both compounds showed an interesting antiproliferative activity with similar potency in all cell lines. By means of flow cytometric studies, hyptadienic acid (2) induced in HeLa cells a S cell cycle block, while 1 elicited both cytostatic and cytotoxic responses. |
| Databáze: | OpenAIRE |
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