The use of 5-aminolaevulinic acid as a photosensitiser in photodynamic therapy and photodiagnosis
| Autor: | Roger Ackroyd, C. J. Kelty, Nicola J. Brown, Malcolm W.R. Reed |
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| Rok vydání: | 2002 |
| Předmět: |
Photosensitizing Agents
Protoporphyrin IX medicine.medical_treatment Photodynamic therapy Aminolevulinic Acid Pharmacology chemistry.chemical_compound Photochemotherapy chemistry Biochemistry Neoplasms diagnosis Neoplasms medicine Humans Cutaneous photosensitivity Physical and Theoretical Chemistry 5 aminolaevulinic acid |
| Zdroj: | Photochemical & Photobiological Sciences. 1:158-168 |
| ISSN: | 1474-9092 1474-905X |
| DOI: | 10.1039/b201027p |
| Popis: | Photodynamic therapy (PDT) is a treatment for cancer and pre-malignant conditions, which involves the administration of a photosensitising agent followed by exposure of the tissue to light. 5-Aminolaevulinic acid (ALA) is a naturally occurring compound in the haem biosynthetic pathway, which is metabolised to a photosensitive product, protoporphyrin IX (PpIX). The major advantage of ALA when compared to synthetic photosensitisers is the rapid metabolism, which significantly reduces the period of cutaneous photosensitivity. This review focuses on the development of ALA as a photosensitiser in photodynamic therapy and photodiagnosis, and the wide range of clinical applications in which ALA is now being used as a therapeutic modality. |
| Databáze: | OpenAIRE |
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