Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure
| Autor: | Gregory D. Lewis, Janice M. Camuso, Jordan T. Shin, David M. Systrom, Justine Lachmann, Marc J. Semigran, Kenneth D. Bloch, John J. Lepore, Maryann E. Martinovic |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Cardiac output Heart disease Sildenafil Cardiac Output Low Hemodynamics Radionuclide ventriculography Blood Pressure Piperazines Sildenafil Citrate chemistry.chemical_compound Ventricular Dysfunction Left Heart Rate Physiology (medical) Internal medicine medicine Humans Sulfones Cardiac Output Exercise business.industry Pulmonary Gas Exchange Middle Aged medicine.disease Pulmonary hypertension Endocrinology medicine.anatomical_structure chemistry Purines Heart failure Vascular resistance Cardiology Exercise Test Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 115(1) |
| ISSN: | 1524-4539 |
| Popis: | Background— Heart failure (HF) is frequently associated with dysregulation of nitric oxide–mediated pulmonary vascular tone. Sildenafil, a type 5 phosphodiesterase inhibitor, lowers pulmonary vascular resistance in pulmonary hypertension by augmenting intracellular levels of the nitric oxide second messenger, cyclic GMP. We tested the hypothesis that a single oral dose of sildenafil (50 mg) would improve exercise capacity and exercise hemodynamics in patients with chronic systolic HF through pulmonary vasodilation. Methods and Results— Thirteen patients with New York Heart Association class III HF underwent assessment of right heart hemodynamics, gas exchange, and first-pass radionuclide ventriculography at rest and with cycle ergometry before and 60 minutes after administration of 50 mg of oral sildenafil. Sildenafil reduced resting pulmonary arterial pressure, systemic vascular resistance, and pulmonary vascular resistance, and increased resting and exercise cardiac index ( P o 2 increased (15±9%) and ventilatory response to CO 2 output (V̇ e /V̇ co 2 slope) decreased (16±5%) after sildenafil treatment. Improvements in right heart hemodynamics and exercise capacity were confined to patients with secondary pulmonary hypertension (rest pulmonary arterial pressure >25 mm Hg). Conclusions— The present study shows that in patients with systolic HF, type 5 phosphodiesterase inhibition with sildenafil improves peak V̇ o 2 , reduces V̇ e /V̇ co 2 slope, and acts as a selective pulmonary vasodilator during rest and exercise in patients with HF and pulmonary hypertension. |
| Databáze: | OpenAIRE |
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