Evaluation of the safety and efficacy of beta blockers in septic patients: a randomized control trial
| Autor: | Eman Mohamed Kamal Aboseif, Mohamed Nabil Mohamed Abdelmaksoud, Hany Victor Zaki, Dalia Ahmed Ibrahim, Raouf Ramzy Gadallah |
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| Rok vydání: | 2020 |
| Předmět: |
Hemodynamics
030204 cardiovascular system & hematology Group B law.invention lcsh:RD78.3-87.3 Sepsis 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Heart rate Medicine 030212 general & internal medicine Mortality Beta (finance) business.industry lcsh:Medical emergencies. Critical care. Intensive care. First aid lcsh:RC86-88.9 General Medicine medicine.disease Pathophysiology lcsh:Anesthesiology Beta Blocker Anesthesia ICU business Complication |
| Zdroj: | Ain Shams Journal of Anesthesiology, Vol 12, Iss 1, Pp 1-9 (2020) |
| ISSN: | 2090-925X |
| Popis: | Background Sepsis is a common fatal complication of an infection. As part of the host response, sympathetic stimulation can result in many serious complications such as septic myocardial depression and metabolic, hematological, and immunological dysfunction. Treatment with beta blockers may reduce this pathophysiological response to infection, but the clinical outcomes are not clear. Results Our study showed a significant difference as regards decrease in heart rate in group B with P value < 0.001 compared to group A, besides a reduction in 28-day mortality (P value 0.0385) and ICU stay (P value < 0.001) in group B compared to group A. Conclusion This study supports the role of intravenous beta blockers in sepsis patients by decreasing heart rate without affecting the hemodynamics, in addition to decreasing 28-day mortality and ICU stay. |
| Databáze: | OpenAIRE |
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