Drug-drug interactions and potentially inappropriate medications among elderly outpatients
| Autor: | Kargar Mona, Heidari Kazem, Javadi Mohammad Reza, Atrianfar Fatemeh, Gholami Kheirollah, Rezaei Fatemeh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Geriatrics
Drug medicine.medical_specialty Zhan criteria business.industry media_common.quotation_subject Potentially Inappropriate Medications Specialty Pharmacy Logistic regression RS1-441 Pharmacy and materia medica Elderly Concomitant hemic and lymphatic diseases Emergency medicine Medicine Drug Interactions Potentially Inappropriate Medication Medical prescription business media_common |
| Zdroj: | Brazilian Journal of Pharmaceutical Sciences, Volume: 57, Article number: e18728, Published: 04 OCT 2021 Brazilian Journal of Pharmaceutical Sciences, Vol 57 (2021) |
| Popis: | The high prevalence of concomitant chronic illnesses and the resulting higher number of medications in the elderly population increase the risk of adverse drug reactions due to drug-drug interactions (DDIs) and potentially inappropriate medications (PIMs). Therefore, the aim of this study was to investigate the prevalence and factors associated with DDIs and PIMs in outpatient geriatrics. In this cross-sectional study, 1512 prescriptions belonging to patients aged ≥65 years from five public pharmacies in Tehran were evaluated. Clinically relevant (C, D, and X) and significant DDIs (D and X) were documented according to the Lexicomp®. Additionally, Zhan criteria were used to detect PIMs. At least one clinically relevant DDI was detected in 61.7% of the prescriptions containing ≥2 medications. The largest percentage of prescriptions with DDIs was prescribed by cardiologists (74.3%). The number of medications in prescriptions and the specialty of the prescriber significantly affected both clinically relevant and significant DDIs in a logistic regression model. At least one PIM was identified in 16.3% of the prescriptions. General practitioners (GPs) were the largest prescribers of PIMs. The mean number of medications was significantly higher in prescriptions with PIMs. In conclusion, clinically relevant DDIs are frequent in the elderly. In terms of PIMs, more attention should be paid to the education of GPs. |
| Databáze: | OpenAIRE |
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