Diversity of cystic fibrosis chronic rhinosinusitis microbiota correlates with different pathogen dominance
| Autor: | Sarah K. Lucas, Ryan C. Hunter, Erin Feddema, Holly C. Boyer |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Cystic Fibrosis medicine.disease_cause Cystic fibrosis Article Microbiology 03 medical and health sciences 0302 clinical medicine Microbial ecology medicine otorhinolaryngologic diseases Humans Microbiome Sinusitis Correlation of Data Rhinitis Lung biology Bacteria Pseudomonas aeruginosa business.industry Microbiota respiratory system medicine.disease Mucus Cystic fibrosis transmembrane conductance regulator 030104 developmental biology medicine.anatomical_structure 030228 respiratory system Pediatrics Perinatology and Child Health Chronic Disease biology.protein business Staphylococcus |
| Zdroj: | J Cyst Fibros |
| ISSN: | 1873-5010 |
| Popis: | Chronic rhinosinusitis (CRS) affects nearly all individuals with cystic fibrosis (CF) and is thought to serve as a reservoir for microbiota that subsequently colonize the lung. To better understand the microbial ecology of CRS, we generated a 16S rRNA gene sequencing profile of sinus mucus from CF-CRS patients. We show that CF-CRS sinuses harbor bacterial diversity not entirely captured by clinical culture. Culture data consistently identified the dominant organism in most patients, though lower abundance bacteria were not always identified. We also demonstrate that bacterial communities dominated by Staphylococcus spp. were significantly more diverse compared to those dominated by Pseudomonas spp. Diversity was not significantly associated with clinical factors or patient age, however, younger subjects yielded a much wider range of bacterial diversity. These data mirror bacterial community dynamics in the lung and provide additional insight into the role of sinus microbiota in chronic airway disease progression. |
| Databáze: | OpenAIRE |
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