Use of a leucocyte filter to remove tumour cells from intra-operative cell salvage blood
| Autor: | S. Williams, Christine Davies, L. Hopkins, M. Rees, O. Freites, S. Catling |
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| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty Intra operative Genital Neoplasms Female medicine.drug_class Ovariectomy Cell Blood Loss Surgical Cell Separation Hysterectomy Monoclonal antibody Blood Transfusion Autologous Blood loss medicine Humans Vein Intraoperative Care business.industry Antibodies Monoclonal Neoplastic Cells Circulating medicine.disease Epithelium Neoplasm Proteins Anesthesiology and Pain Medicine medicine.anatomical_structure Keratins Immunohistochemistry Female Leukocyte Reduction Procedures business Ovarian cancer |
| Zdroj: | Anaesthesia. 63:1332-1338 |
| ISSN: | 1365-2044 0003-2409 |
| DOI: | 10.1111/j.1365-2044.2008.05637.x |
| Popis: | Summary The intra-operative blood loss of 50 consecutive gynae-oncology patients undergoing surgery for endometrial, cervical or ovarian cancer was cell salvaged and filtered. In each case blood samples were taken from the effluent tumour vein, a central venous line, the cell saver reservoir, the cell salvage re-transfusion bag after processing but before filtration and from the cell salvage re-transfusion bag after processing and filtration. Samples were examined using immunohistochemical monoclonal antibody markers for epithelial cell lines. Viable, nucleated malignant cells were detected in 2/50 central venous samples, 34/50 reservoir samples and 31/50 unfiltered cell salvaged samples. After passage through a Pall RS leucocyte depletion filter no remaining viable, nucleated malignant cells were detected in any sample. The clinical risks of cell salvage in these circumstances should be reviewed in the light of the risks of allogeneic blood transfusion. |
| Databáze: | OpenAIRE |
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