ATDC contributes to sustaining the growth and invasion of glioma cells through regulating Wnt/β-catenin signaling
| Autor: | Changwang Du, Yanqiang Wei, Maode Wang, Yidong Cao, Luoning Shi, Juanru Hou |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Dishevelled Proteins Toxicology medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Cell Movement Glioma Cell Line Tumor medicine Gene silencing Humans RNA Small Interfering Wnt Signaling Pathway beta Catenin Cell Proliferation chemistry.chemical_classification Gene knockdown Wnt signaling pathway General Medicine medicine.disease Dishevelled Up-Regulation DNA-Binding Proteins 030104 developmental biology chemistry 030220 oncology & carcinogenesis Cancer research RNA Interference Signal transduction Carcinogenesis Transcription Factors |
| Zdroj: | Chemico-biological interactions. 305 |
| ISSN: | 1872-7786 |
| Popis: | Accumulating evidence has documented that ataxia-telangiectasia group D complementing gene (ATDC) is aberrantly expressed in various cancers and is associated with cancer development and progression. However, little is known about the role of ATDC in glioma tumorigenesis. In this study, we aimed to explore the biological function and regulatory mechanism of ATDC in glioma. We found that ATDC expression was highly upregulated in glioma cell lines. Knockdown of ATDC significantly inhibited the growth and invasion of glioma cells. In contrast, overexpression of ATDC markedly promoted the growth and invasion of glioma cells. Moreover, our results showed that inhibition of ATDC reduced the expression levels of Dishevelled 2 (Dvl2) and β-catenin and impeded the activation of Wnt/β-catenin signaling, whereas overexpression of ATDC showed the opposite effect. Knockdown of Dvl2 significantly blocked the promotion effect of ATDC overexpression on activation of Wnt/β-catenin signaling. In addition, silencing of β-catenin partially reversed the oncogenic effect of ATDC overexpression in glioma cells. Taken together, out study reveals an oncogenic role of ATDC that drives the growth and invasion of glioma by modulating the Wnt/Dvl2/β-catenin signaling pathway, suggesting a potential therapeutic target for treatment of glioma. |
| Databáze: | OpenAIRE |
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