Hypoxia-inducible factor-1α promotes proliferation of airway smooth muscle cells through miRNA-103-mediated signaling pathway under hypoxia

Autor:	Cantang Zhang, Jin Gao, Shuyang Zhu
Rok vydání:	2021
Předmět:	Male Myocytes Smooth Muscle PTEN Phosphohydrolase Bronchi Cell Biology General Medicine Hypoxia-Inducible Factor 1 alpha Subunit Asthma Cell Hypoxia Rats Sprague-Dawley MicroRNAs Gene Expression Regulation Animals Cells Cultured Cell Proliferation Signal Transduction Developmental Biology
Zdroj:	In Vitro Cellular & Developmental Biology - Animal. 57:944-952
ISSN:	1543-706X 1071-2690
DOI:	10.1007/s11626-021-00607-0
Popis:	The hypoxia-inducible factor-1α (HIF-1α) activated during asthma development plays a causative role in the abnormal proliferation of airway smooth muscle (ASM) cells and consequential airway remodeling. Although the underlying mechanisms of HIF-1α activity have not been fully revealed, HIF-1α-regulated miRNA signaling is considered important for disrupted differentiation and proliferation of local cells in various tissues under inflammation. We aimed to identify the key miRNA signaling involved in HIF-1α regulation of the proliferation of ASM cells. This study was based on primary ASM cells isolated from adult male rats. Three percent O
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdcdf5f3dc42707faa61894e0ef269d3 https://doi.org/10.1007/s11626-021-00607-0 Zobrazit plný text záznamu Full text from SpringerLink