Urinary bisphenol A and age at menarche among adolescent girls: Evidence from NHANES 2003–2010
| Autor: | Laura McGuinn, Armen A. Ghazarian, L. Joseph Su, Gary L. Ellison |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
endocrine system
medicine.medical_specialty Bisphenol A Adolescent Urinary system Biochemistry Article Body Mass Index Young Adult chemistry.chemical_compound Breast cancer Phenols Internal medicine medicine Humans Benzhydryl compounds Benzhydryl Compounds Young adult Child General Environmental Science Menarche urogenital system business.industry Nutrition Surveys medicine.disease Environmental Estrogen Cross-Sectional Studies Endocrinology chemistry Female business Body mass index hormones hormone substitutes and hormone antagonists |
| Zdroj: | Environmental Research. 136:381-386 |
| ISSN: | 0013-9351 |
| Popis: | Bisphenol A (BPA) is an environmental estrogen used in the manufacture of polycarbonate plastics and epoxy resins used to make food and beverage packaging. Increasing evidence suggests that BPA mimics estrogens in the body and may be associated with putative markers of breast cancer risk.We analyzed the National Health and Nutrition Examination Survey (NHANES) 2003-2010 data to investigate the association of BPA with age at menarche in adolescent girls. We hypothesized that urinary BPA, as a surrogate biomarker for BPA exposure, is associated with earlier age at menarche, and that body mass index (BMI) may modulate this association.We conducted cross-sectional analyses of urinary BPA, BMI and age of menarche in a subsample of 987 adolescent girls aged 12-19, using pooled data from the 2003-2010 NHANES. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) for the association between urinary BPA and early onset of menarche, with adjustment for sampling design. We additionally assessed interaction of BPA with BMI.Adolescent girls with moderate BPA levels appeared to be less likely to have early onset of menarche than those with the lowest levels (OR=0.57; 95% CI=0.30, 1.08) after adjusting for age, race/ethnicity, parental education, country of birth, NHANES cycle, BMI and creatinine. BMI appeared to modify the BPA-menarche association.Although a non-significant trend suggests increasing urinary BPA may be associated with delayed menarche in adolescent girls, these results are based on cross-sectional data. Results should be clarified in carefully designed longitudinal cohort studies. |
| Databáze: | OpenAIRE |
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