A hydrogel-based implantable multidrug antitubercular formulation outperforms oral delivery
| Autor: | Ujjaini Dasgupta, Raunak Kar, Devashish Mehta, Vijay Soni, Pankaj Sharma, Somesh Jha, Aasheesh Srivastava, Sanjay Pal, Poonam Yadav, Vinay Kumar Nandicoori, Kajal Rana, D Jain, Veena S. Patil, Avinash Bajaj, Nihal Medatwal, Sandeep Kumar |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Antitubercular Agents 02 engineering and technology Pharmacology Mice 03 medical and health sciences Isoniazid Animals Medicine General Materials Science Ethambutol business.industry Therapeutic effect Hydrogels Pyrazinamide 021001 nanoscience & nanotechnology 030104 developmental biology Drug delivery Self-healing hydrogels Chemotherapeutic drugs 0210 nano-technology business Rifampicin medicine.drug |
| Zdroj: | Nanoscale. 13:13225-13230 |
| ISSN: | 2040-3372 2040-3364 |
| DOI: | 10.1039/d0nr08806d |
| Popis: | We present a non-immunogenic, injectable, low molecular weight, amphiphilic hydrogel-based drug delivery system (TB-Gel) that can entrap a cocktail of four front-line antitubercular drugs, isoniazid, rifampicin, pyrazinamide, and ethambutol. We showed that TB-Gel is more effective than oral delivery of the combination of four drugs in reducing the mycobacterial infection in mice. Results show that half the dose of chemotherapeutic drugs is sufficient to achieve a comparable therapeutic effect to that of oral delivery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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