Autor: |
Martin Appelfeller, Chow Saephanh, Divisha Raheja, Suma Babu, Timothée Lenglet, Colleen Newhard, Ira J. Goodman, Agessandro Abrahao, Eoin Finegan, Olga Kwast-Rabben, Mark B. Bromberg, Stephan Goedee, Muhammad Al-Lozi, Tuan Vu, Jonathan D. Glass, Andreas Funke, Annemarie Hübers, Jesper Raaijman, Raul Juntas-Morales, Esther Rosier, Anke Tümmler, Nazem Atassi, Christina Fournier, Shafeeq Ladha, Markus Weber, Takuya Ohkubo, Antonio Canosa, Marion Zakrzewski, Robert C. Bucelli, Amina Coffey, Ron Leppanen, Nancy Hamel, Christoph Neuwirth, Kristl G. Claeys, Nathalie Braun, Toby A. Ferguson, Vinay Chaudhry, Susanne Petri |
Rok vydání: |
2018 |
Předmět: |
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Zdroj: |
Clinical Neurophysiology, 129(8), 1756. Elsevier Ireland Ltd |
ISSN: |
1872-8952 1388-2457 |
Popis: |
Objective: Motor Unit Number Index (MUNIX) is a quantitative neurophysiological method that reflects loss of motor neurons in Amyotrophic Lateral Sclerosis (ALS) in longitudinal studies. It has been utilized in one natural history ALS study and one drug trial (Biogen USA) after training and qualification of raters. Methods: Prior to testing patients, evaluators had to submit test-retest data of 4 healthy volunteers. Twenty-seven centres with 36 raters measured MUNIX in 4 sets of 6 different muscles twice. Coefficient of variation of all measurements had to be |
Databáze: |
OpenAIRE |
Externí odkaz: |
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