Aggregating exposures & cumulating risk for semivolatile organic compounds: A review
Autor: | Maud Pelletier, Nathalie Bonvallot, Philippe Glorennec |
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Přispěvatelé: | Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), 2014-00053331, Fondation de France, TEZ14-36, Agence de l’Environnement et de la maîtrise de l’énergie (Ademe, Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Glorennec, Philippe |
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Cumulating risk 010501 environmental sciences Semivolatile organic compounds Risk Assessment 01 natural sciences Biochemistry 03 medical and health sciences Health risk assessment Contaminants Humans Relative potency 0105 earth and related environmental sciences General Environmental Science Volatile Organic Compounds Chemistry Environmental Exposure Environmental exposure Hazard index Aggregating exposures Hazard quotient 3. Good health Cumulative risk 030104 developmental biology [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie 13. Climate action Environmental chemistry Environmental Pollutants [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Risk assessment Cumulative risk assessment Environmental Monitoring |
Zdroj: | Environmental Research Environmental Research, 2017, 158, pp.649-659. ⟨10.1016/j.envres.2017.06.022⟩ Environmental Research, Elsevier, 2017, 158, pp.649-659. ⟨10.1016/j.envres.2017.06.022⟩ |
ISSN: | 0013-9351 1096-0953 |
Popis: | International audience; Increasingly, health risk assessment is addressing multiple pathway exposures to multiple contaminants. We reviewed aggregated exposure and cumulative risk approaches for contemporary and ubiquitous semivolatile organic compounds (SVOC). We identified 22 studies aggregating exposure pathways, and 31 cumulating risk. Exposure aggregation is based on the addition of pathway-specific doses, using kinetic modeling where it exists, and classic external dose equations otherwise. In most cases, exposure is dominated by a single route or source of exposure - mainly the oral pathway - via dietary or non-dietary exposure. Preferential routes and sources of exposure are influenced by SVOC physical-chemical properties such as vapor pressure. The cumulative risk approach for contaminants is based on dose addition. Simple sum of hazard quotient (Hazard Index: HI) is the most commonly used cumulative risk assessment approach, while Relative Potency Factor (RPF) appeared to the best suited – although this calls for a level of toxicological information that limits the number of compounds that can be studied simultaneously. Where both were performed, moving from HI to more refined approach produced similar results. In conclusion, both approaches - exposure aggregation and cumulative risk - rely on simple assumptions. Nevertheless, they allow uncertainty to be reduced, in comparison with source-by-source or chemical-by-chemical approaches. |
Databáze: | OpenAIRE |
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