Predicting BRAF V600E mutation in glioblastoma: utility of radiographic features
| Autor: | Fausto J. Rodriguez, Kouichirou Okamoto, Ramil Gabdulkhaev, Yoshihiro Tsukamoto, Yu Kanemaru, Akiyoshi Kakita, Yukihiko Fujii, Karisa C. Schreck, Haruhiko Takahashi, Michael Chang, Manabu Natsumeda, Makoto Oishi, Masayasu Okada |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Proto-Oncogene Proteins B-raf Cancer Research Pathology medicine.medical_specialty Neurology Radiography medicine.disease_cause Young Adult medicine Humans neoplasms Aged Mutation Brain Neoplasms business.industry General Medicine Middle Aged medicine.disease Gross Total Resection digestive system diseases nervous system diseases BRAF V600E Oncology Female Neurology (clinical) Glioblastoma business Forecasting |
| Zdroj: | Brain Tumor Pathology. 38:228-233 |
| ISSN: | 1861-387X 1433-7398 |
| DOI: | 10.1007/s10014-021-00407-0 |
| Popis: | Detection of BRAF V600E mutation in glioblastomas (GBMs) is important because of potential therapeutic implications. Still, the relative paucity of these mutations makes molecular detection in all GBMs controversial. In the present study, we analyzed clinical, radiographic and pathologic features of 12 BRAF V600E-mutant GBMs and 12 matched controls from 2 institutions. We found that a majority of BRAF V600E-mutant GBMs displayed a combination of well-circumscribed lesions, large cystic components with thin walls and solid cortical component on MRI, but with some overlap with matched BRAF wildtype controls (p = 0.069). BRAF V600E-mutant GBMs were also apt to gross total resection (83% vs 17%, p = 0.016) and morphologically displayed epithelioid features (83% vs 0%, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink