Evaluation of multifunctional magnesium aluminosilicate materials as novel family of glidants in solid dosage products
| Autor: | Diem Trang Tran, Petr Zámostný, Lukáš Kulaviak, P. Komínová |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Scanning electron microscope Rheometer Mixing (process engineering) Magnesium Compounds Pharmaceutical Science Excipient 02 engineering and technology 030226 pharmacology & pharmacy Dosage form Excipients 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Particle Size Aluminum Compounds Silicates 021001 nanoscience & nanotechnology Microcrystalline cellulose chemistry Glidant Chemical engineering Particle size Powders Rheology 0210 nano-technology medicine.drug |
| Zdroj: | International Journal of Pharmaceutics. 592:120054 |
| ISSN: | 0378-5173 |
| Popis: | The work was aimed at evaluating the efficiency of multifunctional magnesium aluminosilicate materials (MAS) as a novel glidant in solid dosage forms. MAS are known for their very low cohesive interactions and their utilization could avoid the disadvantages associated with conventional glidant usage. Flow properties of several mixtures comprising a model excipient (microcrystalline cellulose) and a glidant were characterized using a powder rheometer FT4. The mixtures were formulated to represent effects of glidant types, various levels of glidant loading, particle size and mixing time on flow properties of the model excipient. Pre-conditioning, shear testing, compressibility, flow energy measurements and an additional tapping test were carried out to monitor flow properties. Mixtures were analyzed employing scanning electron microscopy, using a detector of back-scattered electrons to identify a mechanism of MAS towards improving the mixture flow properties. All studied parameters were found to have substantial effects on mixture flow properties, but the effect of mixing time was much less important compared to mixtures based on traditional glidant. The mechanism of MAS glidant action was found to be different compared to that of traditional one, having less process sensitivity, so that MAS utilization as glidant could be advantageous for the formulation performance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect