The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype
| Autor: | Frank Dicker, Susanne Schnittger, Claudia Haferlach, T Haferlach, H Herholz, Wolfgang Kern, Aki Nakao, Nancy Patten, Lin Wu |
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| Rok vydání: | 2008 |
| Předmět: |
Cancer Research
medicine.medical_specialty Pathology endocrine system diseases Concordance Chronic lymphocytic leukemia Biology medicine.disease_cause Gastroenterology Denaturing high performance liquid chromatography Predictive Value of Tests Internal medicine medicine Humans neoplasms Sequence Deletion Chromosome Aberrations Mutation Hematology Cytogenetics Cancer medicine.disease Prognosis Leukemia Lymphocytic Chronic B-Cell Leukemia Oncology Karyotyping Disease Progression Tumor Suppressor Protein p53 Chromosomes Human Pair 17 |
| Zdroj: | Leukemia. 23(1) |
| ISSN: | 1476-5551 |
| Popis: | The poor prognosis of chronic lymphocytic leukemia (CLL) patients with del (17p) is well established. We analyzed whether mutation of TP53 on the remaining allele adds to the poor prognosis or whether even TP53 mutation alone may be an adverse prognostic factor. We analyzed TP53 mutations in 193 CLL patients by denaturing high performance liquid chromatography in combination with direct DNA sequencing and a TP53 resequencing research microarray. Mutations were correlated to chromosomal aberrations defined by interphase fluorescent in situ hybridization and chromosome banding analyses and to the clinical course of patients. TP53 mutations were detected in 13.5% (26 of 193) of samples, whereas the incidence of del (17p) was 9.3% (18 of 193). TP53 mutations were significantly associated with del (17p) (concordance 94%, P |
| Databáze: | OpenAIRE |
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