Engineering Anisotropic Meniscus: Zonal Functionality and Spatiotemporal Drug Delivery
| Autor: | José Crecente-Campo, María J. Alonso, Anna Abbadessa |
|---|---|
| Přispěvatelé: | Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica |
| Jazyk: | angličtina |
| Předmět: |
musculoskeletal diseases
Materials science 0206 medical engineering Biomedical Engineering Bioengineering 02 engineering and technology Degeneration (medical) Knee Joint Meniscus (anatomy) Biochemistry Biomaterials Tissue engineering Anisotropic tissue regeneration medicine Humans Regeneration Meniscus Tissue Scaffolds Zonal reconstruction 021001 nanoscience & nanotechnology musculoskeletal system 020601 biomedical engineering body regions medicine.anatomical_structure Pharmaceutical Preparations Drug delivery Anisotropy 0210 nano-technology Growth factors Biomedical engineering |
| Zdroj: | Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela Universidad de Santiago de Compostela (USC) Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela instname Tissue Engineering Part B: Reviews |
| ISSN: | 1937-3376 1937-3368 |
| DOI: | 10.1089/ten.teb.2020.0096 |
| Popis: | This document is the preprint manuscript version of a published work that appeared in final form in Tissue Engineering Part B: Reviews, Copyright 2020, Mary Ann Liebert, Inc., publishers after peer review and technical editing by the publisher. To access the final edited and published work see: https://doi.org/10.1089/ten.teb.2020.0096 Human meniscus is a fibrocartilaginous structure that is crucial for an adequate performance of the human knee joint. Degeneration of the meniscus is often followed by partial or total meniscectomy, which enhances the risk of developing knee osteoarthritis. The lack of a satisfactory treatment for this condition has triggered a major interest in drug delivery (DD) and tissue engineering (TE) strategies intended to restore a bioactive and fully functional meniscal tissue. The aim of this review is to critically discuss the most relevant studies on spatiotemporal DD and TE, aiming for a multizonal meniscal reconstruction. Indeed, the development of meniscal tissue implants should involve a provision for adequate active molecules and scaffold features that take into account the anisotropic ultrastructure of human meniscus. This zonal differentiation is reflected in the meniscus biochemical composition, collagen fiber arrangement, and cell distribution. In this sense, it is expected that a proper combination of advanced DD and zonal TE strategies will play a key role in the future trends in meniscus regeneration This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 814444 (MEFISTO); and from Xunta de Galicia’s Grupos de referencia competitiva (grant number ED431C 2017/09) |
| Databáze: | OpenAIRE |
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