Genetic analysis of the hypothalamic neurotensin system
| Autor: | Steven J. Garlow, Becky Kinkead, Charles B. Nemeroff, Ericka M. Boone |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Hypothalamus
Chromosome 9 Nerve Tissue Proteins Biology Quantitative trait locus Chromosomes Mice Animals Receptors Neurotensin Neurotensin receptor Gene Chromosome 12 Neurotensin Pharmacology Genetics Membrane Glycoproteins Structural gene Chromosome Chromosome Mapping Molecular biology Mice Inbred C57BL Psychiatry and Mental health Adaptor Proteins Vesicular Transport Chromosome 3 Gene Expression Regulation Mice Inbred DBA RNA Regression Analysis |
| Zdroj: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 31(3) |
| ISSN: | 0893-133X |
| Popis: | This study used B × D recombinant inbred mice to detect and localize genes that control the hypothalamic neurotensin (NT) system. Abundance of transcripts that encode NT and NT receptors 1, 2, and 3 (NTR1, NTR2, and NTR3) in total hypothalamic RNA was the quantitative trait measured. Analysis of transcript abundance data revealed associations with quantitative trait loci (QTL) for NT transcript abundance (NTta) on chromosome 1, 3, 6, 7, 8, and 9; for NTR1ta on chromosome 3, 8, 12, and X; for NTR2ta on chromosome 2, 4, 9, 10, 12, 13, and 17; for NTR3ta on chromosome 1, 7, 11, and 12. NTta QTL on chromosomes 3, 7, and 8 coincide with QTL previously identified that impact NT peptide content and NTR2ta QTL on chromosome 2 and 12 coincide with genes previously associated with NTR2 receptor abundance. The NTta, NTR1ta, and NTR3ta QTL were not linked to their respective structural genes, but there is a highly significant (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|