Effects of transdermal and oral postmenopausal hormone therapy on vascular function a randomized placebo-controlled study in healthy postmenopausal women
| Autor: | Majoie Hemelaar, W. Marchien van Baal, Marius J. van der Mooren, Casper G. Schalkwijk, Peter Kenemans, Coen D.A. Stehouwer |
|---|---|
| Přispěvatelé: | Interne Geneeskunde, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, RS: CARIM School for Cardiovascular Diseases |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Norpregnenes medicine.medical_treatment Administration Oral Vascular Cell Adhesion Molecule-1 Gestodene Placebo Administration Cutaneous Transdermal estrogen Von Willebrand factor Double-Blind Method Internal medicine medicine.artery von Willebrand Factor Medicine Humans Brachial artery Ultrasonography Doppler Color Transdermal Aged biology Estradiol business.industry Estrogen Replacement Therapy Obstetrics and Gynecology Middle Aged medicine.disease Postmenopause Endocrinology Carotid Arteries Pulsatile Flow biology.protein Arterial stiffness Female Hormone therapy Progestins business E-Selectin Biomarkers medicine.drug |
| Zdroj: | Menopause-The Journal of the North American Menopause Society, 12, 526-535. LIPPINCOTT WILLIAMS & WILKINS |
| ISSN: | 1072-3714 |
| Popis: | Objective: To compare the effect of transdermal and oral estrogen therapy, the latter with or without the addition of gestodene, on plasma concentrations of markers of endothelial function and on ultrasonographic parameters of vascular function in healthy postmenopausal women. Design: In a 15-month, randomized, double-blind, placebo-controlled study, 152 healthy hysterectomized postmenopausal women received daily doses of placebo (n = 49), 50 μg of transdermal 17β-estradiol (tE 2 , n = 33), 1 mg of oral E 2 (oE 2 , n = 37), or 1 mg of oral estradiol combined with 25 μg of gestodene (oE 2 + G, n = 33) for 13 cycles of 28 days, followed by four washout cycles with placebo in each group. At baseline and in cycles 4, 13, and 17, we measured plasma levels of endothelial markers and ultrasonographic markers of vascular function (pulsatility index [PI] and, at baseline and cycle 13, arterial stiffness). Results: Compared with placebo, we found reductions in soluble vascular cell adhesion molecule (oE 2 , P < 0.01; oE 2 + G, P < 0.001), sE-selectin (oE 2 + G, P < 0.05), von Willebrand factor (tE 2 , P < 0.05), and divergent effects in PI and stiffness parameters in the carotid artery. We found no effect on PI in the retinal and femoral arteries, or on stiffness parameters in the femoral and brachial artery. Conclusions: Oral hormone therapy reduced plasma levels of adhesion molecules, whereas transdermal estrogen therapy reduced von Willebrand factor. Effects on ultrasonographic parameters of vascular function in the carotid artery were inconclusive. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|