A genetic marker and family history study of the upstate New York multiple sclerosis cluster
| Autor: | Randolph B. Schiffer, W. J. Hall, L. R. Weitkamp, C. Ford |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Genetic Markers Male Gerontology medicine.medical_specialty Multiple Sclerosis New York Disease Disease cluster Gene Frequency Internal medicine Prevalence medicine Cluster Analysis Humans Family Age of Onset Family history Allele Child Aged chemistry.chemical_classification Mood Disorders business.industry Multiple sclerosis Incidence (epidemiology) Transferrin medicine.disease chemistry Genetic marker Female Neurology (clinical) business |
| Zdroj: | Neurology. 44:329-329 |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | We report nine additional cases of new-onset multiple sclerosis (MS) among employees of an upstate New York manufacturing plant that uses zinc as a primary metal. These cases, identified during the decade 1980 to 1989, had clinical onset of the disease between 1979 and 1987. The new cases confirm the increased incidence of MS previously reported in the plant population for the 1970 to 1979 decade. The MS subjects in this occupationally based cluster do not seem different from other MS patients with regard to rates of familial MS or the frequencies of alleles for human leukocyte (HLA-DR) antigens or transferrin. The frequency distribution of alleles for transferrin (an iron- and zinc-binding protein) may differ in these and other MS subjects compared with controls. |
| Databáze: | OpenAIRE |
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