Long-term follow-up of patients with Buerger’s disease after autologous stem cell therapy

Autor: Evren Ozcinar, Bahadir Inan, Ali İhsan Hasde, Çağdaş Baran, Mehmet Cakici, Rüçhan Akar, Mustafa Şirlak, Serkan Durdu
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
medicine.medical_treatment
autologous bone marrow mononuclear cell
Bone Marrow Cells
030204 cardiovascular system & hematology
stem cell therapy
Transplantation
Autologous
Amputation
Surgical
03 medical and health sciences
0302 clinical medicine
Forearm
Buerger’s disease
medicine
Humans
Longitudinal Studies
Original Investigation
Bone Marrow Transplantation
Buerger's disease
medicine.diagnostic_test
business.industry
Angiography
Thromboangiitis Obliterans
Stem-cell therapy
Digital subtraction angiography
Middle Aged
medicine.disease
Survival Analysis
Surgery
Transplantation
030104 developmental biology
medicine.anatomical_structure
Treatment Outcome
Amputation
Lower Extremity
Female
Cardiology and Cardiovascular Medicine
Complication
business
Zdroj: Anatolian Journal of Cardiology
ISSN: 2149-2271
2149-2263
Popis: Objective: We investigated the long-term results of autologous bone marrow mononuclear cells (ABMMNCs) implantation in patients with Buerger’s disease (BD). Methods: Twenty-eight patients (25 males and 3 females) who had BD and critical unilateral limb ischemia were investigated between April 2003 and August 2005. The patients were administered multiple injections of CD34+ and CD45+ positive ABMMNCs into the gastrocnemius muscle, the intermetatarsal region, and the dorsum of the foot (n=26) or forearm (n=2) and saline injection into the contralateral limb. Results: The mean follow-up time was 139.6±10.5 months. No complication related to stem cell therapy was observed during the follow-up. The ankle–brachial pressure index evaluated at 6 months and 120 months was compared to the baseline scores (p
Databáze: OpenAIRE
Externí odkaz: