Replacement of L-T4 Suppository in MMI Treated Rabbits

Autor:	Yamamoto M, Toshiro Sakurada, Hiroko Toda, Michinao Mizugaki, Kaoru Yoshinaga, Hisako Kikuchi, Kenzo Yonezawa, Shintaro Saito
Rok vydání:	1990
Předmět:	medicine.medical_specialty Methimazole Lagomorpha biology business.industry Suppositories General Engineering Area under the curve Suppository biology.organism_classification Thyroxine Endocrinology Hypothyroidism Internal medicine Anesthesia medicine Animals Triiodothyronine Rabbits business
Zdroj:	Endocrinologia Japonica. 37:355-359
ISSN:	2185-6370 0013-7219
Popis:	L-T4 suppositories containing 50, 100 or 200 micrograms of L-T4 were given to rabbits treated with MMI. The serum T4 gradually increased within 3.5 and 6.5 hours following the use of 100 and 200 micrograms of L-T4 suppositories, respectively, without an acute increase in serum T3. The increase in serum T4 continued up to 48 hours. The area under the curve (AUC) for serum T4 was evidently dose-dependent. It is concluded from these results that the T4 suppository will be useful as a replacement therapy for patients with hypothyroidism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdbc9d554ac052650324b8e120c1f846 https://doi.org/10.1507/endocrj1954.37.355 Zobrazit plný text záznamu