Risk of second primary cancers in women diagnosed with endometrial cancer in G erman and S wedish cancer registries
| Autor: | Mahdi Fallah, Kari Hemminki, Lina Jansen, Tianhui Chen, Leiting Xu, Bernd Holleczek, Alexander Katalinic, Kristina Sundquist, Karla Geiss, Felipe A. Castro, Hermann Brenner, Sabine Luttmann, Meike Ressing |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Adolescent Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Germany Internal medicine Epidemiology of cancer medicine Humans Registries Young adult Aged Aged 80 and over Sweden Gynecology Cancer prevention business.industry Incidence Endometrial cancer Incidence (epidemiology) Cancer Neoplasms Second Primary Middle Aged medicine.disease Endometrial Neoplasms Cancer registry 030104 developmental biology 030220 oncology & carcinogenesis Female business Kidney cancer |
| Zdroj: | International Journal of Cancer. 141:2270-2280 |
| ISSN: | 1097-0215 0020-7136 |
| Popis: | Along with the increasing incidence and favorable prognosis, more women diagnosed with endometrial cancer may develop second primary cancers (SPCs). We aimed at investigating risk of SPCs after endometrial cancer in Germany and Sweden to provide insight into prevention strategies for SPCs. Endometrial cancer patients diagnosed at age ≥15 years in Germany during 1997-2011 and in Sweden nationwide during 1997-2012 were selected. Standardized incidence ratios (SIRs), calculated as the ratio of observed to expected numbers of cases, were used to assess the risk of a specific second cancer after endometrial cancer for both German and Swedish datasets. Among 46,929 endometrial cancer survivors in Germany and 18,646 in Sweden, overall 2,897 and 1,706 SPCs were recorded, respectively. Significantly elevated SIRs were observed in Germany for ovarian (SIR = 1.3; 95%CI:1.1-1.5) and kidney cancers [1.6 (1.3-1.8)], while in Sweden the SIRs were 5.4 (4.6-6.3) and1.4 (1.0-1.9), respectively. Elevated risk for second ovarian endometrioid carcinoma was pronounced after early ( |
| Databáze: | OpenAIRE |
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